The List of New & Deleted CPT Codes 2025!

The 2025 CPT code set has undergone major updates, with the American Medical Association (AMA) implementing 420 changes to keep pace with medical science and healthcare technology advancements. These updates, developed by the CPT Editorial Panel through an open review process, aim to improve coding accuracy and efficiency. Key highlights include:

• Total Changes: 420 updates, including additions, deletions, and revisions
• New Codes: 270 additions, expanding coverage for emerging medical procedures
• Deleted Codes: 49 removals to eliminate outdated procedures
• Revised Codes: 112 modifications for improved clarity and accuracy
• Key Updates: Significant changes in telemedicine, E/M services, skin substitutes, laboratory and pathology services, and Category III technology codes

Below is a detailed breakdown of the newly added and removed CPT codes for 2025.

Evaluation and Management (E/M) Code Updates for 2025

The 2025 CPT code set introduces several significant changes in the Evaluation and Management (E/M) section, particularly in telemedicine services. The latest updates include deleting outdated telephone service codes and introducing a new family of telemedicine codes to improve clarity and coding efficiency.

Key Changes in E/M Codes

• Deleted Codes: Telephone service codes (99441-99443) have been removed.
• New Telemedicine Codes:
  • Synchronous Audio-Video E/M:
    • For new patients: 98000-98003
    • For established patients: 98004-98007
  • Synchronous Audio-Only E/M:
    • For new patients: 98008-98011
    • For established patients: 90012-90015
• New Virtual Check-In Code: 90016 has been introduced for virtual check-in visits.
• Updated Guidelines
  • New section guidelines explain the appropriate use of telemedicine E/M codes based on medical decision-making or total time.
  • A new table in the subsection clarifies coding for telemedicine and non-face-to-face digital services.

These updates aim to enhance accuracy in coding and improve accessibility to telemedicine services.

Surgery CPT Code Updates for 2025

The 2025 CPT code set introduces several important changes across various surgical specialties, including integumentary, musculoskeletal, cardiovascular, digestive, urinary, genital, endocrine, nervous, and ocular systems. 

These updates aim to enhance precision in coding and reflect advancements in surgical techniques and procedures.

Surgery: Integumentary System

• New Codes for Skin Cell Suspension Autograft (SCSA):
  • 15011-15012: Harvesting based on wound size
  • 15013-15014: Preparation based on size
  • 15015-15018: Application categorized by anatomical site and size

Surgery: Musculoskeletal System

• Code Deletion: 21632 (mediastinal lymphadenectomy)
• Code Revision: 21630 was revised to remove the semicolon, making it a standalone code
• New Code: 25448 for intercarpal or carpometacarpal joint arthroplasty with tendon transfer or transplant
• Editorial Update: 25447 revised to become the parent code for 25448

Surgery: Cardiovascular System

• Deleted Codes:
  • 33471: Pulmonary valve valvotomy
  • 33737: Atrial septectomy or septostomy
  • 33813: Obliteration of aortopulmonary septal defect
• Revised Code: 33814 updated to remove the semicolon, no longer a child code

Surgery: Hemic and Lymphatic Systems

• New Codes for CAR-T Therapy:
  • 38225: Harvesting of blood-derived T lymphocytes
  • 38226: Preparation of T lymphocytes for transport
  • 38227: Preparation of CAR-T cells for administration
  • 38228: Administration of CAR-T cells

Surgery: Digestive System

• New Codes for Excision/Destruction of Intra-Abdominal Tumors or Cysts:
  • 49186-49190: Based on tumor/cyst size and method used
• Guidelines:
  • Tumors arising from organs require specific resection codes
  • Separate excision codes apply to additional tumor implants
• Deleted Codes: 49203, 49204, 49205

Surgery: Urinary System

• Deleted Code: 51030 (Cystotomy/cystostomy with cryosurgical destruction)
• Revised Code: 51020 is no longer a parent code for 51030
• New Codes for Prostate and Bladder Procedures:
  • 51721: Transurethral ablation transducer placement for prostate treatment
  • 53865: Insertion of a temporary device for ischemic bladder neck and prostate remodeling
  • 53866: Catheterization for removal of temporary ischemic remodeling device

Surgery: Male Genital System

• New Codes for Prostate Tissue Ablation Using Thermal Ultrasound:
  • 55881: MRI-guided transurethral ablation of prostate tissue
  • 55882: Similar to 55881 but includes transurethral ultrasound transducer placement, suprapubic tube insertion, and endorectal cooling device placement

Surgery: Female Genital System

• Deleted Code: 58957 (Excision of ovary)
• Updated Guidelines: Refer to codes 49186-49190 for tumor debulking related to ovarian, endometrial, tubal, or peritoneal malignancies
• Revised Code: 58958 no longer has a semicolon, becoming a parent code

Surgery: Endocrine System

• New Codes for Thyroid Nodule Ablation Using Radiofrequency:
  • 60660: Ablation of thyroid nodules in a single lobe or the isthmus
  • +60661: Add-on for ablation of thyroid nodules in an additional lobe

Surgery: Nervous System

• New Family of Codes for Thoracic & Lower Extremity Fascial Plane Blocks:
  • Thoracic Blocks:
    • 64466: Unilateral block via injection
    • 64467: Unilateral block via continuous infusion
    • 64468: Bilateral block via injection
    • 64469: Bilateral block via continuous infusion
  • Lower Extremity Blocks:
    • 64473: Unilateral block via injection
    • 64474: Unilateral block via continuous infusion

Surgery: Eye and Ocular Adnexa

• New Code: 66683 for implantation of an iris prosthesis, including suture fixation and iris repair/removal if performed

Radiology CPT Code Updates for 2025

The 2025 CPT code set introduces new Magnetic Resonance (MR) safety assessment codes to address risks associated with implanted medical devices or foreign bodies during MR procedures. These codes help ensure patient safety by covering implant verification, risk assessment, safety planning, and device management before or during an MR exam.

New MR Safety Assessment Codes

• 76014: Initial 15-minute MR safety assessment by trained staff, including implant verification, MR conditional status review, and written report.
• +76015: Add-on code for each additional 30 minutes of MR safety assessment, requiring a written report.
• 76016: MR safety determination by a physician or qualified health professional, including implant risk-benefit analysis and necessary equipment determination, with a written report.
• 76017: Custom MR safety planning and monitoring by a medical physicist or MR safety expert, adjusting MR acquisition based on implant conditions and risk mitigation, with a physician-reviewed report.
• 76018: MR safety preparation of implant electronics, including programming pulse generators or transmitters to protect the patient, supervised by a physician or qualified health professional, with a written report.
• 76019: Implant positioning and/or immobilization under physician supervision to prevent MR-induced forces, movement, or burns, with a written report.

Additional Notes:

• Codes 76017-76019 are modifier 51 multiple procedures exempt, meaning they can be reported without additional reductions when performed with other procedures.
• These codes are listed out of sequence in the CPT manual.

These updates enhance MR safety protocols and provide structured reimbursement for the essential steps to prevent MR-related complications in implant patients.

Pathology and Laboratory CPT Code Updates for 2025

Several updates in Pathology and Laboratory services introduce new disease detection, monitoring, and analysis tests, particularly in multianalyte assays, chemistry, immunology, microbiology, and proprietary laboratory analyses (PLAs). These changes aim to provide better diagnostic options and streamline the testing process across various medical disciplines.

Multianalyte Assays with Algorithmic Analyses (MAAA)

• 81515: Real-time PCR test for detecting bacterial vaginosis and vaginitis using vaginal-fluid specimens.
• 81558: Test used in kidney transplantation to monitor allograft rejection.

Chemistry Tests

• 82233 and 82234: Tests for beta-amyloid related to neurological conditions.
• 83884: Test for neurofilament light chain related to neurodegenerative diseases.
• 84393 and 84395: Tests for tau proteins (phosphorylated and total) linked to Alzheimer's disease and other tauopathies.

Immunology

• 86581: New code for testing Streptococcus pneumoniae antibody (IgG), specific to serotypes.

Microbiology Tests

• 87513: Detection of Helicobacter species via nucleic acid analysis (DNA/RNA).
• 87564: Detection of Mycobacterium tuberculosis.
• 87594: Detection of Pneumocystis jirovecii.

Proprietary Laboratory Analyses (PLAs)

• New codes for multilaboratory tests and genomic sequencing procedures (GSP). This includes tests under the MAAA subsection and for genomic sequencing related to specific diseases.

Medicine CPT Code Updates for 2025

Significant updates in the Medicine section cover new vaccine codes, diagnostic procedures, and genetic services to improve preventive and diagnostic capabilities for healthcare providers.

Influenza Virus Vaccine Product Codes

• 90637: Quadrivalent mRNA influenza vaccine (30 mcg/0.5 mL).
• 90638: Quadrivalent mRNA influenza vaccine (60 mcg/0.5 mL).
• 90695: H5N8 influenza vaccine, derived from cell cultures.

New Add-On Diagnostic Codes

• +93896: Vasoreactivity study.
• +93897: Emboli detection without intravenous microbubble injection.
• +93898: Venous-arterial shunt detection with intravenous microbubble injection.
  • All performed with a complete transcranial Doppler (TCD) study of intracranial arteries (code 93886).

Genetic Services

• 96040 was deleted and replaced with 96041 for medical genetics and genetic counseling services.

Respiratory Syncytial Virus Monoclonal Antibody Administration

• 96380: Administration with counseling.
• 96381: Administration without counseling.

Category III Codes

• New Category III codes for emerging technologies, including:
  • 0870T-0875T for subcutaneous peritoneal ascites pump procedures.
  • 0877T-0881T for augmentative chest CT analysis.
  • 0913T-0914T for intracoronary drug delivery via drug-delivery balloon.

New Major CPT Codes for 2025

The new codes will improve the diagnostic and treatment processes across multiple specialties. These additions reflect advances in specialized fields like psychiatry, oncology, obstetrics, infectious disease, and pharmacogenomics, providing more precise and personalized medical care. Here’s a breakdown of the most significant new additions:

Anesthesiology/Pain Management

• Fascial Plane Blocks (FPB): New codes for regional anesthesia techniques to provide targeted pain relief in specific body regions.

New Major CPT Codes for 2025

• 0477U – Drug Metabolism for Psychiatry: Code for testing drug metabolism in psychiatric care to help personalize treatment.
• 0485U – Oncology (Solid Tumor) Cell-Free DNA and RNA: New code for analyzing cell-free DNA and RNA in solid tumor oncology.
• 0482U – Obstetrics (Preeclampsia) Biochemical Assay: A test to detect preeclampsia in obstetric patients using biochemical assays.
• 0480U – Infectious Disease (Metagenomic Sequencing): Code for metagenomic sequencing detecting infectious diseases.
• 0516U – Pharmacogenomic Drug Metabolism Testing: A new code for pharmacogenomic testing, helping tailor drug prescriptions based on an individual’s genomic profile.

Revised CPT Codes for 2025

As part of the CPT code revisions for 2025, 38 codes have been updated to reflect advancements in medical science and improve care and reimbursement accuracy. These revisions offer more comprehensive descriptions of procedures, helping providers correctly document and be reimbursed for their services. Below is a table of the most significant revised codes for 2025:

Code	Description
64486	Transversus abdominis plane (TAP) block; unilateral, injection
64487	Transversus abdominis plane (TAP) block; unilateral, continuous infusion
64488	Transversus abdominis plane (TAP) block; bilateral, injection
64489	Transversus abdominis plane (TAP) block; bilateral, continuous infusion
93893	Transcranial Doppler study of the intracranial arteries to detect emboli (blood clots)
75774	Vascular Procedures Guidelines revised
0248U	Oncology, spheroid cell culture in a 3D microenvironment, 12-drug panel, brain- or brain metastasis–response prediction
0403U	Oncology (prostate), mRNA gene expression profiling of 18 genes from first-catch urine, with results indicating likelihood of detecting prostate cancer
0615T	Automated analysis of binocular eye movements without spatial calibration for the assessment of concussion
90661	Influenza vaccine, trivalent (ccIIV3), derived from cell cultures, preservative and antibiotic-free, for intramuscular use

CPT Codes Set to be Deleted in 2025

As part of the CPT updates for 2025, 112 codes are being deleted to reflect advancements in medical practices and ensure more accurate coding for current procedures. These deletions remove outdated or redundant codes, streamlining and aligning the coding process with the latest technology and practices. Below are the most significant deletions for 2025:

• 0398T: Magnetic resonance image-guided high-intensity focused ultrasound (MRgFUS)
• 99441: Telephone evaluation and management service lasting 5-10 minutes
• 99442: Telephone evaluation and management service lasting 11-20 minutes
• 99443: Telephone evaluation and management service lasting 21-30 minutes
• 0078U: Pain management (opioid-use disorder) genotyping panel testing for 16 common variants using buccal swab or germline tissue
• 0167U: Gonadotropin, chorionic (hCG), immunoassay with direct optical observation, blood
• 0396U: Obstetrics (preimplantation genetic testing), evaluation of 300,000 DNA SNPs by microarray, embryonic tissue
• 75600-75756: Angiography codes
• 36215-36248: Catheterization codes
• 93890: Vasoreactivity study (associated procedures rolled into updated codes)

Urinary System 2025 CPT Codes

The Urinary System codes for 2025 include a mix of new, revised, and deleted codes to reflect advancements in procedures related to bladder, prostate, and urinary treatments. Notable changes include the deletion of bladder incision codes and the introduction of new transurethral ablation codes. Below are the key updates:

• 51721: Insertion of a transurethral ablation transducer to deliver thermal ultrasound for prostate tissue ablation.
• 55881: Transurethral ablation of prostate tissue using thermal ultrasound, including MRI guidance and monitoring.
• 55882: Transurethral ablation of prostate tissue using thermal ultrasound, including MRI guidance and monitoring, and inserting a transurethral ultrasound transducer.
• 52317 & 52318: Litholapaxy procedures (crushing and removing calculus in the urinary bladder).
• 53865: Cystourethroscopy with the insertion of a temporary device for ischemic remodeling of the bladder, neck, and prostate.
• 53866: Catheterization with the removal of a temporary device for ischemic remodeling of the bladder, neck, and prostate.
• 52214: Cystourethroscopy with fulguration (excluding biopsy).
• 52224: Cystourethroscopy with fulguration or treatment of minor lesions.
• 58597: Female urethral system, excision of the ovary (deleted; now use general surgery codes for reporting).

Endocrine System 2025 CPT Codes

For the Endocrine System, two new codes have been added for percutaneous thyroid ablation procedures, particularly for treating thyroid nodules. These codes include imaging guidance and help streamline reporting:

• 60660: Ablation of one or more thyroid nodules in a single lobe or isthmus, including imaging guidance.
• 60661: Add-on code for the ablation of additional nodules in another lobe.

Nervous System 2025 CPT Codes

The Nervous System section introduces new codes for pain management blocks and neurorrhaphy procedures. These revisions help cover nerve-related treatments more comprehensively:

• 64466-64474: New pain block codes, expanding options for pain management.
• 64486: Transversus abdominis plane (TAP) block, unilateral, by injection.
• 64487: TAP block, unilateral, by continuous infusion.
• 64488: TAP block, bilateral, by injection.
• 64489: TAP block, bilateral, by continuous infusion.
• 64901: Neurorrhaphy with nerve graft.
• 64835: Neurorrhaphy procedures.

BillingFreedom: Your Guide to the Latest CPT Code Updates

BillingFreedom has consistently stayed updated with the latest changes in medical coding, ensuring that healthcare providers are always compliant with the current CPT codes. Whether it's the introduction of new codes for advanced procedures like MRI-monitored ultrasound ablations or revisions in existing codes for better reimbursement, BillingFreedom has continually integrated these updates into its system. 

By maintaining awareness of annual updates, including deletions, revisions, and new code sets, BillingFreedom offers reliable support for accurate billing and coding. 

This commitment to staying current allows healthcare professionals to focus on patient care while ensuring proper reimbursement for services rendered.

For more details about our exceptional medical billing services, please don't hesitate to email us at info@billingfreedom.com or call us at +1 (855) 415-3472. 

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